ABSTRACT
Objective@#The present study was undertaken to evaluate the subchronic oral toxicity of sodium dehydroacetate (DHA-Na) and to determine the point of departure (POD), which is a critical factor in the establishment of an acceptable dietary intake.@*Methods@#DHA-Na was administered once daily by gavage to Sprague-Dawley rats at dose levels of 0.0, 31.0, 62.0, and 124.0 mg/kg BW per day for 90 days, followed by a recovery period of 4 weeks in the control and 124.0 mg/kg BW per day groups. The outcome parameters were mortality, clinical observations, body weights, food consumption, hematology and clinical biochemistry, endocrine hormone levels, and ophthalmic, urinary, and histopathologic indicators. The benchmark dose (BMD) approach was applied to estimate the POD.@*Results@#Significant decreases were found in the 62.0 and 124.0 mg/kg BW groups in terms of the body weight and food utilization rate, whereas a significant increase was found in the thyroid stimulating hormone levels of the 124.0 mg/kg BW group. Importantly, the 95% lower confidence limit on the BMD of 51.7 mg/kg BW was modeled for a reduction in body weight.@*Conclusion@#The repeated-dose study indicated the slight systemic toxicity of DHA-Na at certain levels (62.0 and 124.0 mg/kg BW) after a 90-day oral exposure.
Subject(s)
Animals , Rats , Body Weight , Organ Size , Pyrones , Rats, Sprague-DawleyABSTRACT
Objective To discover the treatment effect of arthroscope combined with proximal humerus osteotomy in Knee inversion osteoarthritis.Methods From April 2012 to December 2016, 126 cases were diagnosed with knee inversion osteoarthritis in our deparment, then we divided them into two groups randomly, 63 in each group, the control group operated with arthroscope, and the observation group operated with arthroscope combined with proximal humerus osteotomy. The treatment effects of the two groups were compared. Results Two groups of patients'HSS score,VAS score,KSS score before surgery have no statistical significance (P＞0.05) . 6 months post-operation, the HSS score and KSS score have significant increase in both groups, while the VAS score has an obviously reduction. The differences between the two groups have statistical significance (P＜0.05), the treatment effects in two groups have statistical significance (P＜0.05), the observation group has better treatment effect than the control group, and in the case of adverse reactions in both groups, there were no statistical significance (P＞0.05) . Conclusion The treatment of middle-aged and elderly people knee inversion osteoarthritis by arthroscope combined with proximal humerus osteotomy could improve the treatment,soit is worth promoting in clinics.